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New modelling approach concerning integrated disease control and cost-effectivity. (English) Zbl 1078.92059

Summary: Two new models for controlling diseases, incorporating the best features of different control measures, are proposed and analyzed. These models would draw from poultry, livestock and government expertise to quickly, cooperatively and cost-effectively stop disease outbreaks. The combination strategy of pulse vaccination and treatment (or isolation) is implemented in both models if the number of infectives reaches the risk level (RL). Firstly, for one time impulsive effect we compare three different control strategies for both models in terms of cost. The theoretical and numerical results show that there is an optimal vaccination and treatment proportion such that integrated pulse vaccination and treatment (or isolation) reaches its minimum in terms of cost. Moreover, this minimum cost of integrated strategy is less than any cost of single pulse vaccination or single treatment.

Secondly, a more realistic case for the second model is investigated based on periodic impulsive control strategies. The existence and stability of periodic solutions with the maximum value of the infectives no larger than RL is obtained. Further, the period $T$ of the periodic solution is calculated, which can be used to estimate how long the infectious population will take to return back to its pre-control level (RL) once integrated control tactics cease. This implies that we can control the disease if we implement the integrated disease control tactics every period $T$. For periodic control strategy, if we aim to control the disease such that the maximum number of infectives is relatively small, our results show that the periodic pulse vaccination is optimal in terms of cost.

##### MSC:
 92D30 Epidemiology 34C25 Periodic solutions of ODE 34A37 Differential equations with impulses 49N90 Applications of optimal control and differential games 93C95 Applications of control theory