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Global stability and periodic solution of the viral dynamics. (English) Zbl 1105.92011

Summary: It is well known that mathematical models provide very important information for the research of human immunodeficiency virus-type 1 and hepatitis C virus (HCV). However, the infection rate of almost all mathematical models is linear. The linearity shows the simple interaction between the T cells and the viral particles.

We consider the classical mathematical model with saturation response of the infection rate. By stability analysis we obtain sufficient conditions on the parameters for the global stability of the infected steady state and the infection-free steady state. We also obtain the conditions for the existence of an orbitally asymptotically stable periodic solution. Numerical simulations are presented to illustrate the results.

MSC:
92C60Medical epidemiology
34C25Periodic solutions of ODE
34D05Asymptotic stability of ODE
34D23Global stability of ODE