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Global stability and periodic solution of a model for HIV infection of CD4 + T cells. (English) Zbl 1117.92040
Summary: It is well-known that mathematical models provide very important information for the research of human immunodeficiency virus-type 1 and hepatitis C virus (HCV). However, the infection rate of almost all mathematical models is linear. The linearity shows the simple interaction between the T cells and the viral particles. We consider the classical mathematical model with non-linear infection rate. The global dynamics of this model is rigorously established. We prove that, if the basic reproduction number R 0 1, the HIV infection is cleared from the T-cells population; if R 0 >1, the HIV infection persists. Further, the existence of a non-trivial periodic solution is also studied by means of numerical simulations.
MSC:
92C60Medical epidemiology
37N25Dynamical systems in biology
34D23Global stability of ODE
34K20Stability theory of functional-differential equations