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Influence of backward bifurcation in a model of hepatitis B and C viruses. (English) Zbl 1188.92017
Summary: In the 1990s, liver transplantation for hepatitis B and C virus (HBV and HCV) related-liver diseases was a very controversial issue since recurrent infection of the graft was inevitable. Significant progress has been made in the prophylaxis and treatment of recurrent hepatitis B/C (or HBV/HCV infection) after liver transplantation. We propose a mathematical model of ordinary differential equations describing the dynamics of the HBV/HCV and its interactions with both liver and blood cells. A single model is used to describe infection of either virus since the dynamics in-host (infected of the liver) are similar. Analyzing the model, we observe that the system shows either a transcritical or a backward bifurcation. Explicit conditions on the model parameters are given for the backward bifurcation to be present. Consequently, we investigate possible factors that are responsible for HBV/HCV infection and assess control strategies to reduce HBV/HCV reinfection and improve graft survival after liver transplantation.
MSC:
92C50Medical applications of mathematical biology
34C60Qualitative investigation and simulation of models (ODE)
34D20Stability of ODE
92C60Medical epidemiology
37N25Dynamical systems in biology
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