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Role of CD4 + T-cell proliferation in HIV infection under antiretroviral therapy. (English) Zbl 1275.92033
The authors study a mathematical model describing the interaction between HIV viruses and CD4+ T cells. Both RT and protease inhibitor treatments are incorporated in the model. They assume that the CD4+ T cells proliferate according to a saturation form which is different from the commonly used logistic proliferation form in the literature. Both local and global analyses are carried out. A backward bifurcation has been observed. The global stability of the unique infected equilibrium has been established by using a new criterion developed by M.Y. Li and J.S. Muldowney which has been successfully utilized by some researchers for some high dimensional systems.
92C50Medical applications of mathematical biology
92C60Medical epidemiology
34C60Qualitative investigation and simulation of models (ODE)
37N25Dynamical systems in biology
34C23Bifurcation (ODE)
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