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Circular binary segmentation for the analysis of array-based DNA copy number data. (English) Zbl 1155.62478

Summary: DNA sequence copy number is the number of copies of DNA at a region of a genome. Cancer progression often involves alterations in the DNA copy number. Newly developed microarray technologies enable simultaneous measurements of copy numbers at thousands of sites in a genome. We have developed a modification of binary segmentation, which we call circular binary segmentation, to translate noisy intensity measurements into regions of equal copy numbers. The method is evaluated by simulation and is demonstrated on cell line data with known copy number alterations and on a breast cancer cell line data set.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
92C40 Biochemistry, molecular biology
92C50 Medical applications (general)

Software:

CGH-Plotter
Full Text: DOI