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Cyclical thrombocytopenia: Characterization by spectral analysis and a review. (English) Zbl 0943.92023
Summary: We have analyzed publisbed platelet time series in four normal individuals and 29 putative cyclical thrombocytopenia patients for evidence of significant $$(p\leq 0.05)$$ cyclicity. Three of the normal individuals (all males) showed significant cycling (periods $$T$$ of 23, 30 and 31 days) as did 15 of the cyclical thrombocytopenia patients ($$T$$ from 13 to 65 days). Cyclical thrombocytopenia seems to be approximately equally prevalent in women and men, though in cases where a definite etiology was suggested an autoimmune origin occurs more frequently in women. We also briefly review the current state of knowledge of the control of platelet production by thrombopoietin (c-Mpl ligand) and previous attempts that have been made to construct mathematical models for the platelet control system.

##### MSC:
 92C50 Medical applications (general) 62M15 Inference from stochastic processes and spectral analysis
##### Keywords:
hematological diseases; platelet time series
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