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A mathematical model of the methionine cycle. (English) Zbl 1439.92089

Summary: Building on the work of M. Martinov et al. [“A substrate switch: a new mode of regulation in themethionine metabolic pathway”, J. Theor. Biol. 204, No. 4, 521–532 (2000; doi:10.1006/jtbi.2000.2035)], a mathematical model is developed for the methionine cycle. A large amount of information is available about the enzymes that catalyse individual reaction steps in the cycle, from methionine to \(S\)-adenosylmethionine to \(S\)-adenosylhomocysteine to homocysteine, and the removal of mass from the cycle by the conversion of homocysteine to cystathionine. Nevertheless, the behavior of the cycle is very complicated since many substrates alter the activities of the enzymes in the reactions that produce them, and some can also alter the activities of other enzymes in the cycle. The model consists of four differential equations, based on known reaction kinetics, that can be solved to give the time course of the concentrations of the four main substrates in the cycle under various circumstances. We show that the behavior of the model in response to genetic abnormalities and dietary deficiencies is similar to the changes seen in a wide variety of experimental studies. We conduct computational “experiments” that give understanding of the regulatory behavior of the methionine cycle under normal conditions and the behavior in the presence of genetic variation and dietary deficiencies.

MSC:

92C40 Biochemistry, molecular biology
92C45 Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)
92-10 Mathematical modeling or simulation for problems pertaining to biology
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