Krupa, Martin; Vidal, Alexandre; Desroches, Mathieu; Clément, Frédérique Mixed-mode oscillations in a multiple time scale phantom bursting system. (English) Zbl 1260.34091 SIAM J. Appl. Dyn. Syst. 11, No. 4, 1458-1498 (2012). Summary: We study mixed-mode oscillations in a model of secretion of GnRH (gonadotropin releasing hormone). The model is a phantom burster consisting of two feedforward coupled FitzHugh-Nagumo systems, with three time scales. The forcing system (regulator) evolves on the slowest scale and acts by moving the slow nullcline of the forced system (secretor). There are three modes of dynamics: pulsatility (transient relaxation oscillation), surge (quasi-steady state), and small oscillations related to the passage of the slow nullcline through a fold point of the fast nullcline. We derive a variety of reductions, taking advantage of the mentioned features of the system. We obtain two results, one on the local dynamics near the fold in the parameter regime corresponding to the presence of small oscillations, and the other on the global dynamics, more specifically on the existence of an attracting limit cycle. Our local result is a rigorous characterization of small canards and sectors of rotation in the case of a folded node with an additional time scale, a feature allowing for a clear geometric argument. The global result gives the existence of an attracting unique limit cycle, which, in some parameter regimes, remains attracting and unique even during passages through a canard explosion. Cited in 17 Documents MSC: 34C60 Qualitative investigation and simulation of ordinary differential equation models 34C15 Nonlinear oscillations and coupled oscillators for ordinary differential equations 34C23 Bifurcation theory for ordinary differential equations 34C26 Relaxation oscillations for ordinary differential equations 34D15 Singular perturbations of ordinary differential equations 34E13 Multiple scale methods for ordinary differential equations 34E15 Singular perturbations for ordinary differential equations 34E17 Canard solutions to ordinary differential equations 70K70 Systems with slow and fast motions for nonlinear problems in mechanics 92B05 General biology and biomathematics Keywords:slow-fast systems; multiple time scales; mixed-mode oscillations; limit cycles; secondary canards; sectors of rotation; folded node; singular perturbation; blow-up; GnRH secretion PDFBibTeX XMLCite \textit{M. Krupa} et al., SIAM J. Appl. Dyn. Syst. 11, No. 4, 1458--1498 (2012; Zbl 1260.34091) Full Text: DOI arXiv