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Ultimate tumor dynamics and eradication using oncolytic virotherapy. (English) Zbl 07274877
Summary: In this paper we study ultimate dynamics of one three-dimensional model for tumor growth under oncolytic virotherapy which describes interactions between cytotoxic T-cells, uninfected tumor cells and infected tumor cells. Using the localization theorem of compact invariant sets we derive ultimate upper bounds for all cell populations and establish the property of the existence of the attracting set. Next, we find several conditions under which our system demonstrates convergence dynamics to equilibrium points located in invariant planes corresponding cases of the absence of uninfected or infected tumor cells. These assertions mean global eradication of uninfected or infected tumor cell populations and are presented as algebraic inequalities respecting virus replication rate \(\theta\). In particular, we find in Theorems 4 and 5 the following curious phenomenon. Namely, when we vary \(\theta\) from the instability range of the infected tumor free equilibrium point to the stability range we obtain in the latter range convergence dynamics to one of tumor free equilibrium points; this means that the local eradication of infected tumor cells implies their global eradication. Besides, we give conditions under which the infected tumor cell population persists. Our theoretical studies are supplied by results of numerical simulation.
MSC:
34C60 Qualitative investigation and simulation of ordinary differential equation models
34C05 Topological structure of integral curves, singular points, limit cycles of ordinary differential equations
34C11 Growth and boundedness of solutions to ordinary differential equations
34D20 Stability of solutions to ordinary differential equations
34D05 Asymptotic properties of solutions to ordinary differential equations
92C37 Cell biology
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