##
**Adaptive rejection Metropolis sampling within Gibbs sampling.**
*(English)*
Zbl 0893.62110

Summary: Gibbs sampling is a powerful technique for statistical inference. It involves little more than sampling from full conditional distributions, which can be both complex and computationally expensive to evaluate. W. R. Gilks and P. Wild [ibid. 41, No. 2, 337-348 (1992)] have shown that in practice full conditionals are often log-concave, and they proposed a method of adaptive rejection sampling for efficiently sampling from univariate log-concave distributions.

In this paper, to deal with non-log-concave full conditional distributions, we generalize adaptive rejection sampling to include a Hastings-Metropolis algorithm step. One important field of application in which statistical models may lead to non-log-concave full conditionals is population pharmacokinetics. Here, the relationship between drug dose and blood or plasma concentration in a group of patients typically is modelled by using nonlinear mixed effects models. Often, the data used for analysis are routinely collected hospital measurements, which tend to be noisy and irregular. Consequently, a robust (\(t\)-distributed) error structure is appropriate to account for outlying observations and/or patients. We propose a robust nonlinear full probability model for population pharmacokinetic data. We demonstrate that our method enables Bayesian inference for this model, through an analysis of antibiotic administration in new-born babies.

In this paper, to deal with non-log-concave full conditional distributions, we generalize adaptive rejection sampling to include a Hastings-Metropolis algorithm step. One important field of application in which statistical models may lead to non-log-concave full conditionals is population pharmacokinetics. Here, the relationship between drug dose and blood or plasma concentration in a group of patients typically is modelled by using nonlinear mixed effects models. Often, the data used for analysis are routinely collected hospital measurements, which tend to be noisy and irregular. Consequently, a robust (\(t\)-distributed) error structure is appropriate to account for outlying observations and/or patients. We propose a robust nonlinear full probability model for population pharmacokinetic data. We demonstrate that our method enables Bayesian inference for this model, through an analysis of antibiotic administration in new-born babies.

### MSC:

62P10 | Applications of statistics to biology and medical sciences; meta analysis |

65C99 | Probabilistic methods, stochastic differential equations |

92C45 | Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) |