×

Atrial modulation of sinoatrial pacemaker rate. (English) Zbl 0925.92054

Summary: Atrial tissue is known to modulate the pacemaker activity of the sinoatrial node, and it is suggested that acetylcholine (ACh) applied to the atrium can slow the sinoatrial pacemaker. These experimental observations are explained using a two coupled cell, and a coupled fibre, model of sinoatrial nodal and atrial tissue.

MSC:

92C30 Physiology (general)
PDF BibTeX XML Cite
Full Text: DOI

References:

[1] Kodama, I.; Boyett, M.R., Regional differences in the electrical activity of the rabbit sinus node, Pflugers arch., 404, 214-226, (1985)
[2] Opthof, T.; Vanginneken, A.C.G.; Bouman, L.N.; Jongsma, H.J., The intrinsic cycle length in small pieces isolated from the rabbit sinoatrial node, J. molec. cell. cardiol., 19, 923-934, (1987)
[3] Kirchof, C.J.H.J.; Bonke, F.I.M.; Allessie, M.A.; Lammers, W.J.E.P., The influence of the atrial myocardium on impulse formation in the rabbit sinus node, Pflugers arch., 410, 198-203, (1987)
[4] Winslow, R.L.; Kimball, A.L.; Varghese, A.; Noble, D., Simulation cardiac sinus and atrial network dynamics on the connect machine, Physica, D64, 281-298, (1993) · Zbl 0769.92010
[5] Löffelholz, K.; Pappano, A.J., The parasympathetic neuroeffector junction of the heart, Pharmacol. rev., 37, 1-24, (1985)
[6] Brown, G.L.; Eccles, J.C., The action of a single vagal volley on the rhythm of the heart beat, J. physiol., 82, 211-240, (1934)
[7] Pappano, A.J., Vagal stimulation of the heartbeat: muscarinic receptor hypothesis, J. cardiovasc. electrophys., 2, 262-273, (1991)
[8] M. R. Boyett, I. Kodama, H. Honjo, A. Arai and R. Suzuki, The role of the hyperpolarization-activated current and the muscarinic K^{+} current in the chronotropic effect of ACh on the sinoatrial node isolated from the rabbit, J. Physiol., in press.
[9] Holden, A.V.; Zhang, H., Modelling propagation and re-entry in anisotropic and smoothly heterogeneous cardiac tissue, J. chem. soc. Faraday trans., 89, 2833-2837, (1993)
[10] DiFrancesco, D.; Noble, D., A model of cardiac electrical activity incorporating ionic pumps and concentration changes, Phil. trans. R. soc., B307, 353-398, (1985)
[11] Earm, Y.E.; Noble, D., A model for the single atrial cell: relation between calcium current and calcium release, (), 83-96
[12] Noble, D.; Noble, S.J., A model for sino-atrial node electrical activity based on a modification of the difrancesco-noble (1984) equations, (), 295-305
[13] Noble, D., OXSOFT heart manual, (1988), Version 2.1. 25 Beaumont St., Oxford OX1 2NP, U.K.
[14] Eagan, T.M.; Noble, S.J., Acetylcholine and the Mammalian ‘slow inward’ current: a computer investigation, (), 315-337
[15] Wick, R.Ten; Nawrath, H.; McDonald, T.F.; Trautein, W., On the mechanism of the negative iontropic effect of acetylcholine, Pflugers arch., 361, 207-213, (1976)
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. It attempts to reflect the references listed in the original paper as accurately as possible without claiming the completeness or perfect precision of the matching.