Mukhopadhyay, Saurabh; Bolognese, James A. Determining average bioequivalence and corresponding sample sizes in general asymmetric settings. (English) Zbl 0973.62102 Sankhyā, Ser. B 62, No. 1, 162-174 (2000). Summary: A new approach has been developed for bioequivalence testing to avoid impractical rejections which may occur with the commonly used W.J. Westlake’s [Biometrics 42, 741-744 (1976)] symmetric interval procedure. These methods are shown to cover the original symmetric confidence interval approach as a special case. Also, it is of considerable interest from the manufacturer’s point of view, to obtain the minimum sample size which guarantees a pre-specified power to the test. The calculation of this minimum sample size accounts for the plausible asymmetry in the equivalence range and plausible non-zero expected value of the true difference. Algorithms are provided with illustrations for both testing and sample size problems. MSC: 62P10 Applications of statistics to biology and medical sciences; meta analysis 62F25 Parametric tolerance and confidence regions Keywords:clinical trials; confidence intervals; crossover design; minimum sample size; bioequivalence Citations:Zbl 0337.62025 PDFBibTeX XMLCite \textit{S. Mukhopadhyay} and \textit{J. A. Bolognese}, Sankhyā, Ser. B 62, No. 1, 162--174 (2000; Zbl 0973.62102)