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**Design and analysis of cross-over trials.
2nd ed.**
*(English)*
Zbl 1103.62108

Monographs on Statistics and Applied Probability 98. Boca Raton, FL: Chapman and Hall/CRC (ISBN 0-412-60640-2/hbk). xxv, 382 p. (2003).

Publisher’s description: The first edition from 1989, see the review Zbl 0729.62068, quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, this long-awaited second edition of this classic text retains its predecessor’s careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope.

Enhancements in the second edition include: A new chapter on bioequivalence; Recently developed methods for analyzing longitudinal continuous and categorical data; Real-world examples using the SAS system. A comprehensive catalog of designs, datasets, and SAS programs is available on a companion Web site at www.crcpress.com

Enhancements in the second edition include: A new chapter on bioequivalence; Recently developed methods for analyzing longitudinal continuous and categorical data; Real-world examples using the SAS system. A comprehensive catalog of designs, datasets, and SAS programs is available on a companion Web site at www.crcpress.com

### MSC:

62P10 | Applications of statistics to biology and medical sciences; meta analysis |

62K99 | Design of statistical experiments |

62-02 | Research exposition (monographs, survey articles) pertaining to statistics |