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Importance sampling and the two-locus model with subdivided population structure. (English) Zbl 1144.62092
Summary: The diffusion-generator approximation technique developed by M. De Iorio and R. C. Griffiths [ibid. 36, No. 2, 417–433 (2004; Zbl 1045.62111)] is a very useful method of constructing importance-sampling proposal distributions. Being based on general mathematical principles, the method can be applied to various models in population genetics. In this paper we extend the technique to the neutral coalescent model with recombination, thus obtaining novel sampling distributions for the two-locus model. We consider the case with subdivided population structure, as well as the classic case with only a single population. In the latter case we also consider the importance-sampling proposal distributions suggested by P. Fearnhead and P. Donnelly [Genetics 159, 1299–1318 (2001); see also J. R. Stat. Soc., Ser. B 64, No. 4, 657–680 (2002; Zbl 1067.62111)], and show that their two-locus distributions generally differ from ours. In the case of the infinitely-many-alleles model, our approximate sampling distributions are shown to be generally closer to the true distributions than are Fearnhead and Donnelly’s.

62P10 Applications of statistics to biology and medical sciences; meta analysis
93E25 Computational methods in stochastic control (MSC2010)
60G40 Stopping times; optimal stopping problems; gambling theory
92D10 Genetics and epigenetics
62L15 Optimal stopping in statistics
Full Text: DOI
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