Bayesian alignment of similarity shapes. (English) Zbl 1454.62361

Summary: We develop a Bayesian model for the alignment of two point configurations under the full similarity transformations of rotation, translation and scaling. Other work in this area has concentrated on rigid body transformations, where scale information is preserved, motivated by problems involving molecular data; this is known as form analysis. We concentrate on a Bayesian formulation for statistical shape analysis. We generalize the model introduced by P. J. Green and the first author [Biometrika 93, No. 2, 235–254 (2006; Zbl 1153.62020)] for the pairwise alignment of two unlabeled configurations to full similarity transformations by introducing a scaling factor to the model. The generalization is not straightforward, since the model needs to be reformulated to give good performance when scaling is included. We illustrate our method on the alignment of rat growth profiles and a novel application to the alignment of protein domains. Here, scaling is applied to secondary structure elements when comparing protein folds; additionally, we find that one global scaling factor is not in general sufficient to model these data and, hence, we develop a model in which multiple scale factors can be included to handle different scalings of shape components.


62P10 Applications of statistics to biology and medical sciences; meta analysis
62F15 Bayesian inference


Zbl 1153.62020
Full Text: DOI arXiv Euclid


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