Dissection of a model for neuronal parabolic bursting. (English) Zbl 0628.92016

We have obtained new insight into the mechanisms for bursting in a class of theoretical models. We study R. E. Plant’s model [ibid. 11, 15- 32 (1981; Zbl 0449.92008)] for Aplysia R-15 to illustrate our view of these so-called “parabolic” bursters, which are characterized by low spike frequency at the beginning and end of a burst. By identifying and analyzing the fast and slow processes we show how they interact mutually to generate spike activity and the slow wave which underlies the burst pattern. Our treatment is essentially the first step of a singular perturbation approach presented from a geometrical viewpoint and carried out numerically with AUTO [E. Doedel, Numerical mathematics and computing, Proc. 10th Manitoba Conf., Winnipeg/Manitoba 1980, Congr. Numerantium 30, 265-284 (1981; Zbl 0511.65064)].
We determine the solution sets (steady state and oscillatory) of the fast subsystem with the slow variables treated as parameters. These solutions form the slow manifold over which the slow dynamics then define a burst trajectory. During the silent phase of a burst, the solution trajectory lies approximately on the steady state branch of the slow manifold and during the active phase of spiking, the trajectory sweeps through the oscillation branch.
The parabolic nature of bursting arises from the (degenerate) homoclinic transition between the oscillatory branch and the steady state branch. We show that, for some parameter values, the trajectory remains strictly on the steady state branch (to produce a resting steady state or a pure slow wave without spike activity) or strictly in the oscillatory branch (continuous spike activity without silent phases).
Plant’s model has two slow variables: a calcium conductance and the intracellular free calcium concentration, which a potassium conductance. We also show how bursting arises from an alternative mechanism in which calcium inactivates the calcium current and the potassium conductances is insensitive to calcium. These and other biophysical interpretations are discussed.


92Cxx Physiological, cellular and medical topics
92C05 Biophysics


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