Bayesian detection of embryonic gene expression onset in C. elegans. (English) Zbl 1454.62345

Hu, Jie; Zhao, Zhongying; Yalamanchili, Hari Krishna; Wang, Junwen; Ye, Kenny; Fan, Xiaodan

Ann. Appl. Stat. 9, No. 2, 950-968 (2015).

Summary: To study how a zygote develops into an embryo with different tissues, large-scale 4D confocal movies of C. elegans embryos have been produced recently by experimental biologists. However, the lack of principled statistical methods for the highly noisy data has hindered the comprehensive analysis of these data sets. We introduced a probabilistic change point model on the cell lineage tree to estimate the embryonic gene expression onset time. A Bayesian approach is used to fit the 4D confocal movies data to the model. Subsequent classification methods are used to decide a model selection threshold and further refine the expression onset time from the branch level to the specific cell time level. Extensive simulations have shown the high accuracy of our method. Its application on real data yields both previously known results and new findings.

MSC:

62P10	Applications of statistics to biology and medical sciences; meta analysis
62-08	Computational methods for problems pertaining to statistics

Keywords:

4D confocal microscopy; embryonic onset; change point detection; Bayesian method

References:

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