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A posterior probability approach for gene regulatory network inference in genetic perturbation data. (English) Zbl 1388.62338
Summary: Inferring gene regulatory networks is an important problem in systems biology. However, these networks can be hard to infer from experimental data because of the inherent variability in biological data as well as the large number of genes involved. We propose a fast, simple method for inferring regulatory relationships between genes from knockdown experiments in the NIH LINCS dataset by calculating posterior probabilities, incorporating prior information. We show that the method is able to find previously identified edges from TRANSFAC and JASPAR and discuss the merits and limitations of this approach.

62P10 Applications of statistics to biology and medical sciences; meta analysis
62F15 Bayesian inference
92D10 Genetics and epigenetics
92C42 Systems biology, networks
Full Text: DOI
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