Modeling of breast cancer through evolutionary game theory. (English) Zbl 1408.92008

Summary: We present a simple mathematical model of the development and progression of breast cancer based on evolutionary game theory. Four types of cellular populations are considered: stromal (native) cells, macrophages, benign tumor cells, and motile (malignant) tumor cells. Despite the relative simplicity of the model, it provides a way to explore the interactions between the various cell types and suggests potential approaches to managing and treating cancer.


92C50 Medical applications (general)
91A22 Evolutionary games
91A80 Applications of game theory
Full Text: DOI Link


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