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An ASP-based approach for attractor enumeration in synchronous and asynchronous Boolean networks. (English) Zbl 07453124

Bogaerts, Bart (ed.) et al., Proceedings of the 35th international conference on logic programming (technical communications), ICLP 2019, Las Cruces, USA, September 20–25, 2019. Waterloo: Open Publishing Association (OPA). Electron. Proc. Theor. Comput. Sci. (EPTCS) 306, 295-301 (2019).
Summary: Boolean networks are conventionally used to represent and simulate gene regulatory networks. In the analysis of the dynamic of a Boolean network, the attractors are the objects of a special attention. In this work, we propose a novel approach based on Answer Set Programming (ASP) to express Boolean networks and simulate the dynamics of such networks. Our work focuses on the identification of the attractors, it relies on the exhaustive enumeration of all the attractors of synchronous and asynchronous Boolean networks. We applied and evaluated the proposed approach on real biological networks, and the obtained results indicate that this novel approach is promising.
For the entire collection see [Zbl 1464.68003].

MSC:

68N17 Logic programming

Software:

ASP-G
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References:

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