Electrotonic coupling between two CA3 hippocampal pyramidal neurons: A distributed cable model with somatic gap-junction. (English) Zbl 0835.92009

Poznanski, R. R.; Gibson, W. G.; Bennett, M. R.

Bull. Math. Biol. 57, No. 6, 865-881 (1995).

Summary: A model of a pair of electrotonically coupled CA3 hippocampal pyramidal neurons is presented. Each neuron is represented by a tapered equivalent cable attached to an isopotential soma. The synaptic potential in a neuron soma is determined as a consequence of electrical coupling to another soma that receives a synaptic input on its dendritic tree. Estimates of the coupling resistances, soma input resistances and soma- to-dendritic tree conductance ratio show that a substantial current may arise in a neuron as a consequence of synaptic activity in a neuron coupled to it. The small increase in decay time due to coupling in the model indicates that actual coupling is between more than just pairs of neurons.

MSC:

92C20	Neural biology
78A70	Biological applications of optics and electromagnetic theory
92C05	Biophysics

Keywords:

pair of electrotonically coupled CA3 hippocampal pyramidal neurons; synaptic potential; coupling resistances; soma input resistances; soma- to-dendritic tree conductance ratio