An unbiased test for the bioequivalence problem. (English) Zbl 0905.62107

The authors treat the problem demonstrating bioequivalence of treatments. The standard two one-sided tests procedure for bioequivalence is biased, so they construct an unbiased \(\alpha\)-level test. Since, in the construction, the rejection region of the unbiased test contains that of the two one-sided tests procedure, it is seen that the unbiased test is uniformly more powerful than the \(\alpha\)-level two-sided test procedure. The construction is numerically complemented and also the critical region is illustrated.


62P10 Applications of statistics to biology and medical sciences; meta analysis
62F03 Parametric hypothesis testing
Full Text: DOI


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