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Nonparametric approaches to the analysis of crossover studies. (English) Zbl 1100.62568
Summary: We illustrate nonparametric, and particularly rank-based analyses of crossover studies, designs in which each subject receives more than one treatment over time. Principles involved in using the Wilcoxon rank sum test in the simple two-period, two-treatment crossover designs are described through theory and example. We then extend the ideas to two-treatment designs with more than two periods and to three-treatment, three-period designs. When more than one nonparametric approach is available, we consider the issue of statistical power in choosing an appropriate test.

MSC:
62G10 Nonparametric hypothesis testing
62P10 Applications of statistics to biology and medical sciences; meta analysis
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