A multivariate family-based association test using generalized estimating equations: FBAT-GEE. (English) Zbl 1139.62317

Summary: We propose a multivariate extension of family-based association tests based on generalized estimating equations. The test can be applied to multiple phenotypes and to phenotypic data obtained in longitudinal studies without making any distributional assumptions for the phenotypic observations. Methods for handling missing phenotypic information are discussed. Further, we compare the power of the multivariate test with permutation tests and with using separate tests for each outcome which are adjusted for multiple testing. Application of the proposed test to an asthma study illustrates the power of the approach.


62H15 Hypothesis testing in multivariate analysis
62P10 Applications of statistics to biology and medical sciences; meta analysis
62G10 Nonparametric hypothesis testing
62N03 Testing in survival analysis and censored data
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