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Combining dependent tests for linkage or association across multiple phenotypic traits. (English) Zbl 1141.62355

Summary: A robust statistical method to detect linkage or association between a genetic marker and a set of distinct phenotypic traits is to combine univariate trait-specific test statistics for a more powerful overall test. This procedure does not need complex modeling assumptions, can easily handle the problem with partially missing trait values, and is applicable to the case with a mixture of qualitative and quantitative traits. We propose a simple test procedure along this line, and show its advantages over the standard combination tests for linkage or association in the literature through a data set from the Genetic Analysis Workshop 12 (GAW12) and an extensive simulation study.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
92D10 Genetics and epigenetics
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