New approach to minimize dispersion induced by turn in capillary electrophoresis channel flows. (English) Zbl 1144.76309

Summary: The mechanism of dispersion induced by turn in the capillary electrophoresis channel flows was analyzed firstly. Then the mathematical model of electroosmotic flow is built, and the dispersion of the flow, with different distribution of charge at inner and outer wall in the turns, was simulated numerically using the finite differential method. A new approach of altering the distribution of charge at inner and outer wall in the turns was presented, based on the computational results, to minimize the dispersion induced by turn. Meanwhile, an optimization algorithm to analyze the numerical results and determine the optimal distribution of charge in the turns was also developed. It is found that the dispersion induced by turn in the capillary electrophoresis channel flows could be significantly suppressed by this approach.


76D55 Flow control and optimization for incompressible viscous fluids
76D45 Capillarity (surface tension) for incompressible viscous fluids
76W05 Magnetohydrodynamics and electrohydrodynamics
76R50 Diffusion
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[1] Culbertson C T, Jacobson S C, Ramsey J M. Dispersion sources for compact geometries on microchips[J].Analytical Chemistry, 1998,70(18):3781–3789. · doi:10.1021/ac9804487
[2] Paegel B M, Lester D H, Simpson P C,et al. Turn geometry for minimizing band broadening in microfabricated capillary electrophoresis channels[J].Analytical Chemistry, 2000,72(14): 3030–3037. · doi:10.1021/ac000054r
[3] Molho J I, Herr A E, Mosier B P,et al. Optimization of turn geometries for microchip electrophoresis[J].Analytical Chemistry, 2001,73(7):1350–1360. · doi:10.1021/ac001127+
[4] Qiao R, Aluru N R. Dispersion control in nano-channel system by localized zeta-potential variations[J].Sensors and Actuators A: Physical, 2003,104(3):268–274. · doi:10.1016/S0924-4247(03)00029-3
[5] Schwer C, Kenndler E. Electrophoresis in fused-silica capillaries–the influence of organic-solvents on the electroosmotic velocity and the zeta-potential[J]Analytical Chemistry, 1991,63 (17):1801–1807. · doi:10.1021/ac00017a026
[6] Moseley M A, Deterding L J, Tomer K B,et al. Determination of bioactive peptides using capillary zone electrophoresis mass-spectrometry[J].Analytical Chemistry, 1991,63(2):114–120. · doi:10.1021/ac00002a006
[7] Johnson T J, Ross D, Gaitan M,et al. Laser modification of performed polymer microchannels: application to reduced band broadening around turns subject to electrokinetic flow[J].Analytical Chemistry, 2001,73(15):3656–3661. · doi:10.1021/ac010269g
[8] Hayes M A. Extension of external voltage control of electroosmosis to high-pH buffers[J].Analytical Chemistry, 1990,71(17):3793–3798. · doi:10.1021/ac990301v
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