Dynamical behavior of a delay virus dynamics model with CTL immune response. (English) Zbl 1204.34110

From the abstract: The dynamical behaviour of a virus dynamics model with CTL immune response and time delay is studied. Time delay is used to describe the time between the infected cell and the emission of viral particles on a cellular level. The effect of time delay on the stability of the equilibria of the CTL immune response model is studied and sufficient criteria for local asymptotic stability of the disease-free equilibrium, immune-free equilibrium and endemic equilibrium and global asymptotic stability of the disease-free equilibrium are given. Some conditions for Hopf bifurcation at the immune-free equilibrium and the endemic equilibrium are also obtained by using the time delay as a bifurcation parameter. Numerical simulation with some hypothetical sets of data is carried out to support the analytical findings.


34K60 Qualitative investigation and simulation of models involving functional-differential equations
34K18 Bifurcation theory of functional-differential equations
34K20 Stability theory of functional-differential equations
92C60 Medical epidemiology
Full Text: DOI


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