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Techniques for regularization parameter and hyper-parameter selection in PET and SPECT imaging. (English) Zbl 1217.62092
Summary: Penalized maximum likelihood methods are commonly used in positron emission tomography (PET) and single photon emission computed tomography (SPECT). Due to the fact that a Poisson data-noise model is typically assumed, standard regularization parameter choice methods, such as the discrepancy principle or generalized cross validation, cannot be directly applied. In recent work of the authors [see SIAM J. Sci. Comput. 32, No. 1, 171--185 (2010; Zbl 1215.65116); ibid. 25, No. 4, 1326--1343 (2003; Zbl 1061.65047)] , regularization parameter choice methods for penalized negative-log Poisson likelihood problems are introduced. We apply these methods to the applications of PET and SPECT, introducing a modification that improves the performance of the methods. We then demonstrate how these techniques can be used to choose the hyper-parameters in a Bayesian hierarchical regularization approach.

62H35Image analysis (statistics)
92C55Biomedical imaging and signal processing, tomography
65J22Inverse problems (numerical methods in abstract spaces)
65K10Optimization techniques (numerical methods)
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