Global stability of an HIV-1 infection model with saturation infection and intracellular delay. (English) Zbl 1222.34101

Author’s abstract: An HIV-1 infection model with a saturation infection rate and an intracellular delay accounting for the time between viral entry into a target cell and the production of new virus particles is investigated. By analyzing the characteristic equations, the local stability of an infection-free equilibrium and a chronic-infection equilibrium of the model is established. By using suitable Lyapunov functionals and the LaSalle invariant principle, it is proved that if the basic reproduction ratio is less than one, the infection-free equilibrium is globally asymptotically stable; if the basic reproduction ratio is greater than one, the chronic-infection equilibrium is globally asymptotically stable.


34K60 Qualitative investigation and simulation of models involving functional-differential equations
92C50 Medical applications (general)
92D30 Epidemiology
34K20 Stability theory of functional-differential equations
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