Optimal control of a fed-batch fermentation involving multiple feeds. (English) Zbl 1242.49087

Summary: A nonlinear dynamical system, in which the feed rates of glycerol and alkali are taken as the control functions, is first proposed to formulate the fed-batch culture of 1,3-propanediol (1,3-PD) production. To maximize the 1,3-PD concentration at the terminal time, a constrained optimal control model is then presented. A solution approach is developed to seek the optimal feed rates based on control vector parametrization method and improved differential evolution algorithm. The proposed methodology yield an increase by 32.17% of 1,3-PD concentration at the terminal time.


49N90 Applications of optimal control and differential games
49M30 Other numerical methods in calculus of variations (MSC2010)
Full Text: DOI


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