Kurland, Brenda F.; Johnson, Laura L.; Egleston, Brian L.; Diehr, Paula H. Longitudinal data with follow-up truncated by death: match the analysis method to research aims. (English) Zbl 1328.62574 Stat. Sci. 24, No. 2, 211-222 (2009). Summary: Diverse analysis approaches have been proposed to distinguish data missing due to death from nonresponse, and to summarize trajectories of longitudinal data truncated by death. We demonstrate how these analysis approaches arise from factorizations of the distribution of longitudinal data and survival information. Models are illustrated using cognitive functioning data for older adults. For unconditional models, deaths do not occur, deaths are independent of the longitudinal response, or the unconditional longitudinal response is averaged over the survival distribution. Unconditional models, such as random effects models fit to unbalanced data, may implicitly impute data beyond the time of death. Fully conditional models stratify the longitudinal response trajectory by time of death. Fully conditional models are effective for describing individual trajectories, in terms of either aging (age, or years from baseline) or dying (years from death). Causal models (principal stratification) as currently applied are fully conditional models, since group differences at one timepoint are described for a cohort that will survive past a later timepoint. Partly conditional models summarize the longitudinal response in the dynamic cohort of survivors. Partly conditional models are serial cross-sectional snapshots of the response, reflecting the average response in survivors at a given timepoint rather than individual trajectories. Joint models of survival and longitudinal response describe the evolving health status of the entire cohort. Researchers using longitudinal data should consider which method of accommodating deaths is consistent with research aims, and use analysis methods accordingly. Cited in 21 Documents MSC: 62N05 Reliability and life testing 62-07 Data analysis (statistics) (MSC2010) Keywords:censoring; generalized estimating equations; longitudinal data; missing data; quality of life; random effects models; truncation by death × Cite Format Result Cite Review PDF Full Text: DOI arXiv Euclid References: [1] Burke, G. L., Arnold, A. M., Bild, D. E., Cushman, M., Fried, L. P., Newman, A., Nunn, C. and Robbins, J. (2001). Factors associated with healthy aging: the cardiovascular health study. Journal of the American Geriatrics Society 49 254-262. [2] De Gruttola, V. and Tu, X. M. (1994). Modelling progression of CD4-lymphocyte count and its relationship to survival time. 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