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The role of family-based designs in genome-wide association studies. (English) Zbl 1329.62430
Summary: Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.

62P10 Applications of statistics to biology and medical sciences; meta analysis
92D10 Genetics and epigenetics
Full Text: DOI Euclid
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