On the definition of a confounder. (English) Zbl 1347.62017

VanderWeele, Tyler J.; Shpitser, Ilya

Ann. Stat. 41, No. 1, 196-220 (2013).

Summary: The causal inference literature has provided a clear formal definition of confounding expressed in terms of counterfactual independence. The literature has not, however, come to any consensus on a formal definition of a confounder, as it has given priority to the concept of confounding over that of a confounder. We consider a number of candidate definitions arising from various more informal statements made in the literature. We consider the properties satisfied by each candidate definition, principally focusing on (i) whether under the candidate definition control for all “confounders” suffices to control for “confounding” and (ii) whether each confounder in some context helps eliminate or reduce confounding bias. Several of the candidate definitions do not have these two properties. Only one candidate definition of those considered satisfies both properties. We propose that a “confounder” be defined as a pre-exposure covariate \(C\) for which there exists a set of other covariates \(X\) such that effect of the exposure on the outcome is unconfounded conditional on \((X,C)\) but such that for no proper subset of \((X,C)\) is the effect of the exposure on the outcome unconfounded given the subset. We also provide a conditional analogue of the above definition; and we propose a variable that helps reduce bias but not eliminate bias be referred to as a “surrogate confounder.” These definitions are closely related to those given by J. M. Robins and H. Morgenstern [Comput. Math. Appl. 14, 869–916 (1987; Zbl 0647.62093)]. The implications that hold among the various candidate definitions are discussed.

MSC:

62A01	Foundations and philosophical topics in statistics
62J99	Linear inference, regression
62P10	Applications of statistics to biology and medical sciences; meta analysis

Keywords:

causal inference; causal diagrams; counterfactual; confounder; minimal sufficiency

Citations:

Zbl 0647.62093

Software:

TETRAD

References:

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