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Mixed effects models with censored data with application to HIV RNA levels. (English) Zbl 1059.62661
Summary: Mixed effects models are often used for estimating fixed effects and variance components in longitudinal studies of continuous data. When the outcome being modelled is a laboratory measurement, however, it may be subject to lower and upper detection limits (i.e., censoring). In this paper, the usual EM estimation procedure for mixed effects models is modified to account for left and/or right censoring.

62P10 Applications of statistics to biology and medical sciences; meta analysis
62N02 Estimation in survival analysis and censored data
62N01 Censored data models
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