NONMEM swMATH ID: 8344 Software Authors: Beal, S.L.; Sheiner, L.B. Description: NONMEM® is a nonlinear mixed effects modelling tool used in population pharmacokinetic/pharmacodynamic analysis. NONMEM stands for NONlinear Mixed Effects Modeling. NONMEM is a computer program that is implemented in Fortran90/95. It solves pharmaceutical statistical problems in which within subject and between subjects variability is taken into account when fitting a pharmacokinetic and/or pharmacodynamic (PK/PD) model to data. The appropriate statistical analysis using the appropriate model helps pharmaceutical companies determine appropriate dosing strategies for their products, and increases their understanding of drug mechanisms and interactions.NONMEM software was originally developed by Lewis Sheiner and Stuart Beal and the NONMEM Project Group at the University of California, and has been used for over 30 years for population analysis by many pharmaceutical companies and the PK/PD modeling community. Its continued development and improvement by ICON Development Solutions assures pharmaceutical companies that they may continue to use the analysis tool with which they are familiar for present day pharmaceutical development. Homepage: http://www.iconplc.com/technology/products/nonmem/ Related Software: R; S-PLUS; SAS; MEMSS; Stan; lme4; WinBUGS; ADIFOR; SAS/STAT; SASmixed; PSM; Monolix; mixedsde; nlmixr; Mathematica; NLMEModeling; Matlab; npde; saemix; skewlmm Cited in: 34 Documents all top 5 Cited by 82 Authors 3 Verotta, Davide 2 Concordet, Didier 2 Davidian, Marie 2 De Nicolao, Giuseppe 2 Demidenko, Eugene 2 Wang, Jing 1 Antic, J. 1 Bae, Suk Joo 1 Beal, Stuart L. 1 Bell, Bradley M. 1 Benson, Neil 1 Bickel, Peter John 1 Boscardin, W. John 1 Burger, D. M. 1 Cao, Jiguo 1 Carvalho, Alexandra M. 1 Chafaï, Djalil 1 Chierici, Marco 1 Chinchilli, Vernon M. 1 Cobelli, Claudio 1 Crespi, Catherine M. 1 Danhof, Meindert 1 D’Argenio, David Z. 1 Dejongh, Joost 1 Demin, Oleg V. 1 Dey, Dipak Kumar 1 Drovandi, Christopher C. 1 Dunne, Adrian 1 Estabrook, Ryne 1 Freijer, Jan I. 1 Ge, Zhiyu 1 Grimm, Kevin J. 1 Gudmand-Hoeyer, Johanne 1 Haagensen, Janus 1 Hartford, A. 1 Heinzl, Felix 1 Karelina, Tatiana A. 1 Karimi, Belhal 1 Kim, Seong-Joon 1 Ko, Hyejin 1 Lachos Dávila, Víctor Hugo 1 Laffont, C. M. 1 Laporte, C. J. L. 1 Lavielle, Marc 1 Lee, Sik-Yum 1 Lin, Xihong 1 Marchesi, L. 1 Moulines, Eric 1 Neve, Marta 1 Nunez, Olivier G. 1 Ottesen, Johnny Tom 1 Pettitt, Anthony N. 1 Pillonetto, Gianluigi 1 Ploeger, Bart A. 1 Post, Teun M. 1 Pu, Kewei 1 Ram, Nilam 1 Ramsay, James O. 1 Rice, John A. 1 Rockstroh, J. K. 1 Ryan, Elizabeth G. 1 Saccomani, Maria Pia 1 Schaedeli, Franziska 1 Schlattmann, Peter 1 Schumacher, Fernanda L. 1 Schumitzky, Alan 1 Sheiner, Lewis B. 1 Spormann, Alfred M. 1 Thomaseth, Karl 1 Timmermann, Stine 1 Tomás, Elson 1 Tutz, Gerhard E. 1 van der Graaf, Piet H. 1 Vinga, Susana 1 Vinogradova, Svetlana V. 1 Vonesh, Edward F. 1 Wang, Li 1 Wang, Xiaoning 1 Wolfinger, Russell D. 1 Xu, Liang 1 Yang, Katherine 1 Zhudenkov, Kirill V. all top 5 Cited in 19 Serials 10 Computational Statistics and Data Analysis 2 Mathematical Biosciences 2 Automatica 2 Biometrics 2 Statistics and Computing 2 Wiley Series in Probability and Statistics 1 Bulletin of Mathematical Biology 1 Applied Mathematics and Computation 1 Journal of the American Statistical Association 1 Journal of Computational and Applied Mathematics 1 Computational Statistics 1 Communications in Statistics. Simulation and Computation 1 Complexity 1 Journal of Applied Statistics 1 Computational & Mathematical Methods in Medicine 1 Journal of Statistical Theory and Practice 1 Journal of Theoretical Biology 1 Statistics for Biology and Health 1 Methodology in the Social Sciences all top 5 Cited in 7 Fields 28 Statistics (62-XX) 12 Biology and other natural sciences (92-XX) 7 Numerical analysis (65-XX) 4 Systems theory; control (93-XX) 1 Partial differential equations (35-XX) 1 Probability theory and stochastic processes (60-XX) 1 Computer science (68-XX) Citations by Year