PSMIX swMATH ID: 13670 Software Authors: Wu, B.; Liu, N.; Zhao, H. Description: PSMIX: an R package for population structure inference via maximum likelihood method. Background: Inference of population stratification and individual admixture from genetic markers is an integrative part of a study in diverse situations, such as association mapping and evolutionary studies. Bayesian methods have been proposed for population stratification and admixture inference using multilocus genotypes and widely used in practice. However, these Bayesian methods demand intensive computation resources and may run into convergence problem in Markov Chain Monte Carlo based posterior samplings. Results: We have developed PSMIX, an R package based on maximum likelihood method using expectation-maximization algorithm, for inference of population stratification and individual admixture. Conclusion: Compared with software based on Bayesian methods (e.g., STRUCTURE), PSMIX has similar accuracy, but more efficient computations. PSMIX and its supplemental documents are freely available at http://bioinformatics.med.yale.edu/PSMIX Homepage: http://bioinformatics.dreamhosters.com/?page_id=113 Dependencies: R Related Software: Frappe; STRUCTURE; BGLR; vegan; R; ANCESTRYMAP; Eigenstrat; ADMIXMAP; BAPS 2; Haploview Cited in: 4 Publications all top 5 Cited by 18 Authors 2 Allison, David B. 1 Bingham, Ella 1 de los Campos, Gustavo 1 Divers, Jasmin 1 Lehermeier, Christina 1 Limdi, Nita A. 1 Liu, Nianjun 1 Mannila, Heikki 1 Padilla, Miguel A. 1 Patki, Amit 1 Pérez-Rodríguez, Paulino 1 Pomp, Daniel 1 Redden, David T. 1 Tiwari, Hemant Kumar 1 Vaughan, Laura K. 1 Vazquez, Ana I. 1 Veturi, Yogasudha 1 Zhao, Hongyu Cited in 3 Serials 2 Computational Statistics and Data Analysis 1 Statistics and Its Interface 1 Journal of Agricultural, Biological, and Environmental Statistics Cited in 2 Fields 4 Statistics (62-XX) 2 Biology and other natural sciences (92-XX) Citations by Year