ODoSE swMATH ID: 16945 Software Authors: Michiel Vos, Tim A. H. te Beek, Marc A. van Driel, Martijn A. Huynen, Adam Eyre-Walker, Mark W. J. van Passel Description: ODoSE: A Webserver for Genome-Wide Calculation of Adaptive Divergence in Prokaryotes. Quantifying patterns of adaptive divergence between taxa is a major goal in the comparative and evolutionary study of prokaryote genomes. When applied appropriately, the McDonald-Kreitman (MK) test is a powerful test of selection based on the relative frequency of non-synonymous and synonymous substitutions between species compared to non-synonymous and synonymous polymorphisms within species. The webserver ODoSE (Ortholog Direction of Selection Engine) allows the calculation of a novel extension of the MK test, the Direction of Selection (DoS) statistic, as well as the calculation of a weighted-average Neutrality Index (NI) statistic for the entire core genome, allowing for systematic analysis of the evolutionary forces shaping core genome divergence in prokaryotes. ODoSE is hosted in a Galaxy environment, which makes it easy to use and amenable to customization and is freely available at www.odose.nl. Homepage: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062447 Related Software: itsmr; FastQC; Nebula; Cistrome; ITSM2000; R Cited in: 1 Document Cited by 2 Authors 1 Brockwell, Peter J. 1 Davis, Richard A. Cited in 1 Serial 1 Springer Texts in Statistics Cited in 2 Fields 1 Probability theory and stochastic processes (60-XX) 1 Statistics (62-XX) Citations by Year