I-TASSER swMATH ID: 17207 Software Authors: A. Roy, A. Kucukural, Y. Zhang Description: I-TASSER: a unified platform for automated protein structure and function prediction. The iterative threading assembly refinement (I-TASSER) server is an integrated platform for automated protein structure and function prediction based on the sequence-to-structure-to-function paradigm. Starting from an amino acid sequence, I-TASSER first generates three-dimensional (3D) atomic models from multiple threading alignments and iterative structural assembly simulations. The function of the protein is then inferred by structurally matching the 3D models with other known proteins. The output from a typical server run contains full-length secondary and tertiary structure predictions, and functional annotations on ligand-binding sites, Enzyme Commission numbers and Gene Ontology terms. An estimate of accuracy of the predictions is provided based on the confidence score of the modeling. This protocol provides new insights and guidelines for designing of online server systems for the state-of-the-art protein structure and function predictions. The server is available at http://zhanglab.ccmb.med.umich.edu/I-TASSER. Homepage: http://zhanglab.ccmb.med.umich.edu/I-TASSER/ Related Software: BLAST; PSI-BLAST; CHARMM; MODELLER; SWISS-MODEL; PROCHECK; Gromacs; COFACTOR; STRING; InterProScan; LINCS; ExPASy; VaxiJen; SCWRL4; Tensor2Tensor; DeepGOPlus; DeepGO; QAUST; ProTranslator; GOLabeler Cited in: 14 Publications all top 5 Cited by 60 Authors 2 Lulu, Sajitha 1 Aguilar-Ruiz, Jesus Salvador 1 Amani, Jafar 1 Anupama, Rani 1 Asencio-Cortes, Gualberto 1 Babbar, Anshu 1 Babu, Subramanian 1 Bortz, David M. 1 Cang, Zixuan 1 Chatrabnous, Nazanin 1 Chaudhry, Uma 1 Dehghani, Behzad 1 Divina, Federico 1 Fattahian, Yaser 1 Figueiredo Neto, Manoel 1 Figueiredo, Marxa L. 1 Gargari, Seyed Latif Mousavi 1 Ghasabi, Farzane 1 Halaji, Mehrdad 1 Hasanshahi, Zahra 1 Hashempoor, Tayebeh 1 Heinke, Florian 1 Hoque, Md Tamjidul 1 Iqbal, Sumaiya 1 Jahangiri, Abolfazl 1 Jalali, Marziyeh 1 Joulaei, Hassan 1 Kolora, Sree Rohit Raj 1 Kudryavtseva, S. S. 1 Kumari, Sweta 1 Labudde, Dirk 1 Madhusmita, Rout 1 Mahapatra, Rajani Kanta 1 Mamchur, A. A. 1 Marquez-Chamorro, Alfonso Eduardo 1 Mendenhall, A. R. 1 Mishra, Avdesh 1 Moayedi, Javad 1 Mohana Priya, Arumugam 1 Mousavi, Zahra 1 Mu, Lin 1 Mukherjee, Amitava 1 Opron, Kristopher 1 Panina, I. S. 1 Rahbar, Mohammad Reza 1 Rasooli, Iraj 1 Rout, Subhashree 1 Saluja, Daman 1 Sandstrom, Gunnar 1 Stanishneva-Konovalova, T. B. 1 Tanwer, Pooja 1 Tauqueer, Mohammad 1 Vino, Sundararajan 1 Wang, Sheng 1 Wei, Guowei 1 Wentz, Jacqueline M. 1 Wu, Kedi 1 Xia, Kelin 1 Xu, Hanwen 1 Yaroshevich, I. A. all top 5 Cited in 7 Serials 7 Journal of Theoretical Biology 1 Bulletin of Mathematical Biology 1 PAA. Pattern Analysis and Applications 1 Lobachevskii Journal of Mathematics 1 Computational & Mathematical Methods in Medicine 1 International Journal of Biomathematics 1 Molecular Based Mathematical Biology Cited in 3 Fields 14 Biology and other natural sciences (92-XX) 1 Computer science (68-XX) 1 Operations research, mathematical programming (90-XX) Citations by Year