DFBAlab swMATH ID: 21873 Software Authors: Gomez, J; Höffner, K; Barton, P Description: DFBAlab: a fast and reliable MATLAB code for dynamic flux balance analysis. Background: Dynamic Flux Balance Analysis (DFBA) is a dynamic simulation framework for biochemical processes. DFBA can be performed using different approaches such as static optimization (SOA), dynamic optimization (DOA), and direct approaches (DA). Few existing simulators address the theoretical and practical challenges of nonunique exchange fluxes or infeasible linear programs (LPs). Both are common sources of failure and inefficiencies for these simulators. Results: DFBAlab, a MATLAB-based simulator that uses the LP feasibility problem to obtain an extended system and lexicographic optimization to yield unique exchange fluxes, is presented. DFBAlab is able to simulate complex dynamic cultures with multiple species rapidly and reliably, including differential-algebraic equation (DAE) systems. In addition, DFBAlab’s running time scales linearly with the number of species models. Three examples are presented where the performance of COBRA, DyMMM and DFBAlab are compared. Conclusions: Lexicographic optimization is used to determine unique exchange fluxes which are necessary for a well-defined dynamic system. DFBAlab does not fail during numerical integration due to infeasible LPs. The extended system obtained through the LP feasibility problem in DFBAlab provides a penalty function that can be used in optimization algorithms. Homepage: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-014-0409-8 Dependencies: Matlab Related Software: Matlab; libMC; COBRApy; COBRA Toolbox; Gurobi; CPLEX; BARON; Ipopt; JuMP; ANTIGONE; Julia; CVXPY; Matplotlib; METRADE; MoNeRe; KEGG; COMSTAT; iDynoR; FiPy; DAKOTA Cited in: 7 Documents all top 5 Cited by 15 Authors 3 Barton, Paul I. 2 Khan, Kamil A. 1 Dochain, Denis 1 Gomez, Jose Alberto 1 Harwood, Stuart M. 1 Höffner, Kai 1 Latif, Majid jun. 1 May, Elebeoba E. 1 Noack, Stephan 1 Rapaport, Alain 1 Song, Yingkai 1 Taylor, Josh A. 1 von Lieres, Eric 1 Wiechert, Wolfgang 1 Zhao, Xiao Cited in 5 Serials 2 Bulletin of Mathematical Biology 2 Journal of Optimization Theory and Applications 1 Journal of Mathematical Biology 1 MCSS. Mathematics of Control, Signals, and Systems 1 Mathematical Programming. Series A. Series B Cited in 4 Fields 6 Operations research, mathematical programming (90-XX) 3 Biology and other natural sciences (92-XX) 2 Numerical analysis (65-XX) 1 Systems theory; control (93-XX) Citations by Year