Signal-CF swMATH ID: 26854 Software Authors: Chou, K. C.; Shen, H. B. Description: Signal-CF: a subsite-coupled and window-fusing approach for predicting signal peptides. We have developed an automated method for predicting signal peptide sequences and their cleavage sites in eukaryotic and bacterial protein sequences. It is a 2-layer predictor: the 1st-layer prediction engine is to identify a query protein as secretory or non-secretory; if it is secretory, the process will be automatically continued with the 2nd-layer prediction engine to further identify the cleavage site of its signal peptide. The new predictor is called Signal-CF, where C stands for ”coupling” and F for ”fusion”, meaning that Signal-CF is formed by incorporating the subsite coupling effects along a protein sequence and by fusing the results derived from many width-different scaled windows through a voting system. Signal-CF is featured by high success prediction rates with short computational time, and hence is particularly useful for the analysis of large-scale datasets. Signal-CF is freely available as a web-server at http://chou.med.harvard.edu/bioinf/Signal-CF/ or http://202.120.37.186/bioinf/Signal-CF/. Homepage: https://www.ncbi.nlm.nih.gov/pubmed/17434148 Related Software: Cell-PLoc; Memtype-2L; Euk-mPLoc; Signal-3L; ProtIdent; EzyPred; GPCR-CA; Hum-mPLoc; HIVcleave; Hum-PLoc; GPCR-GIA; AAindex; Euk-PLoc; Phobius; Virus-ploc; Gpos-PLoc; LIBSVM; PSI-BLAST; BLAST; FoldRate Cited in: 28 Documents all top 5 Cited by 98 Authors 3 Georgiou, Dimitrios N. 3 Karakasidis, Theodoros E. 3 Nieto Roig, Juan Jose 3 Torres, Angela 2 Brahnam, Sheryl 2 Chou, Kuochen 2 Deng, Naiyang 2 Guo, Yanzhi 2 Jahandideh, Mina 2 Jahandideh, Samad 2 Li, Menglong 2 Lumini, Alessandra 2 Nanni, Loris 2 Shao, Xiaojian 2 Tian, Yingjie 2 Wu, Lingyun 2 Yu, Lezheng 1 Abdolmaleki, Parviz 1 Anand, Ashish 1 Anh, Vo V. 1 Araabi, Babak Nadjar 1 Barfeie, Mahdyar 1 Çalık, Pınar 1 Cheng, Feng 1 de Magalhães, Alexandre Lopes 1 Ding, Yongsheng 1 Du, Qishi 1 Esmaeili, Maryam 1 Frenkel, Zakharia M. 1 Frenkel, Zeev M. 1 González Díaz, Humberto 1 Han, Libin 1 Hoseini, Afsaneh 1 Hoseini, Somayyeh 1 Huang, Dan 1 Huang, Ri-Bo 1 Huang, Wei 1 Jing, Ling 1 Kavousi, Kaveh 1 Kung, Sunyuan 1 Li, Gongbing 1 Li, Jia-Huang 1 Li, Yizhou 1 Liu, Xin 1 Luo, Jiesi 1 Mak, Man-Wai 1 Massahi, Aslan 1 Megaritis, Athanasios C. 1 Miri Disfani, Fatemeh 1 Mishra, Pooja 1 Mohabatkar, Hassan 1 Mohsenzadeh, Sasan 1 Moosavi-Movahedi, Ali Akbar 1 Moshiri, Behzad 1 Munteanu, Cristian Robert 1 Pandey, Paras Nath 1 Pang, Zong-Wen 1 Peng, Qinke 1 Peng, Zhen-Ling 1 Perez-Bello, Alcides 1 Qin, Wenli 1 Sadeghi, Mehdi 1 Sarvestani, Amir Sabet 1 Schulman, Ira G. 1 Shi, Jianyu 1 Snir, Sagi 1 Suganthan, Ponnuthurai Nagaratnam 1 Theodorescu, Dan 1 Trifonov, Edward N. 1 Ubeira, Florencio M. 1 Uriarte, Eugenio 1 Wan, Shibiao 1 Wang, Desheng 1 Wang, Jin 1 Wang, Tianming 1 Wang, Xiaobo 1 Wang, Yong 1 Wang, Yongcui 1 Wang, Yurong 1 Wei, Hang 1 Wei, Yu-Tuo 1 Xiao, Rong-quan 1 Xiong, Wenjia 1 Xu, Tao 1 Xu, Yan 1 Yang, Jianyi 1 Yang, Jie 1 Yang, Li 1 Yang, Lianping 1 Yu, Zuguo 1 Zeng, Yuhong 1 Zhang, Chenyu 1 Zhang, Jianmin 1 Zhang, Ruijie 1 Zhang, Tongliang 1 Zhang, Xiangde 1 Zhao, Yapu 1 Zhong, Tao Cited in 3 Serials 26 Journal of Theoretical Biology 1 Journal of Intelligent and Fuzzy Systems 1 Computational Biology and Chemistry all top 5 Cited in 7 Fields 28 Biology and other natural sciences (92-XX) 10 Computer science (68-XX) 9 Statistics (62-XX) 2 Combinatorics (05-XX) 1 Mathematical logic and foundations (03-XX) 1 Game theory, economics, finance, and other social and behavioral sciences (91-XX) 1 Information and communication theory, circuits (94-XX) Citations by Year