swMATH ID: 26858
Software Authors: Shen, H.B.; Chou, K.C.
Description: EzyPred: a top-down approach for predicting enzyme functional classes and subclasses. Given a protein sequence, how can we identify whether it is an enzyme or non-enzyme? If it is, which main functional class it belongs to? What about its sub-functional class? It is important to address these problems because they are closely correlated with the biological function of an uncharacterized protein and its acting object and process. Particularly, with the avalanche of protein sequences generated in the Post Genomic Age and relatively much slower progress in determining their functions by experiments, it is highly desired to develop an automated method by which one can get a fast and accurate answer to these questions. Here, a top-down predictor, called EzyPred, is developed by fusing the results derived from the functional domain and evolution information. EzyPred is a 3-layer predictor: the 1st layer prediction engine is for identifying a query protein as enzyme or non-enzyme; the 2nd layer for the main functional class; and the 3rd layer for the sub-functional class. The overall success rates for all the three layers are higher than 90
Homepage: https://www.ncbi.nlm.nih.gov/pubmed/17931599
Related Software: Cell-PLoc; Signal-CF; Memtype-2L; ProtIdent; Signal-3L; Euk-mPLoc; HIVcleave; GPCR-CA; iNuc-PhysChem; LIBSVM; Hum-mPLoc; Hum-PLoc; GPCR-GIA; iRSpot-TNCPseAAC; PseAAC; Euk-PLoc; iRSpot-PseDNC; iLoc-Hum; iLoc-Animal; PseAAC-Builder
Referenced in: 16 Publications

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