Hum-PLoc swMATH ID: 26863 Software Authors: Chou KC, Shen HB Description: Hum-PLoc: a novel ensemble classifier for predicting human protein subcellular localization. Predicting subcellular localization of human proteins is a challenging problem, especially when unknown query proteins do not have significant homology to proteins of known subcellular locations and when more locations need to be covered. To tackle the challenge, protein samples are expressed by hybridizing the gene ontology (GO) database and amphiphilic pseudo amino acid composition (PseAA). Based on such a representation frame, a novel ensemble classifier, called ”Hum-PLoc”, was developed by fusing many basic individual classifiers through a voting system. The ”engine” of these basic classifiers was operated by the KNN (K-nearest neighbor) rule. As a demonstration, tests were performed with the ensemble classifier for human proteins among the following 12 locations: (1) centriole; (2) cytoplasm; (3) cytoskeleton; (4) endoplasmic reticulum; (5) extracell; (6) Golgi apparatus; (7) lysosome; (8) microsome; (9) mitochondrion; (10) nucleus; (11) peroxisome; (12) plasma membrane. To get rid of redundancy and homology bias, none of the proteins investigated here had > or = 25 Homepage: https://www.ncbi.nlm.nih.gov/pubmed/16808903 Related Software: Cell-PLoc; Euk-mPLoc; Euk-PLoc; Hum-mPLoc; Memtype-2L; LIBSVM; Gpos-PLoc; Virus-ploc; Plant-mPLoc; PseAAC; Signal-CF; iLoc-Euk; ProtIdent; EzyPred; Gneg-mPLoc; SecretP; GPCR-2L; MemHyb; PseAAC-General; BLAST Cited in: 22 Publications all top 5 Cited by 57 Authors 5 Hayat, Maqsood 2 Chen, Yingli 2 Jahandideh, Samad 2 Khan, Asifullah 2 Li, Qianzhong 2 Mei, Suyu 1 Abdolmaleki, Parviz 1 Ahmad, Jamal 1 Ahmad, Saeed 1 Anand, Ashish 1 Anh, Vo V. 1 Barfeie, Mahdyar 1 Cao, Shengjiao 1 Chen, Chao 1 Chou, Kuochen 1 de Magalhães, Alexandre Lopes 1 Du, Pufeng 1 Esmaeili, Maryam 1 González Díaz, Humberto 1 Huang, Yan 1 Iqbal, Nadeem 1 Jahandideh, Mina 1 Khan, Muazzam Ali 1 Khan, Muslim 1 Khan, Sher Afzal 1 Khan, Zaheer Ullah 1 Kurgan, Lukasz A. 1 Li, Dachao 1 Li, Yanda 1 Li, ZhanChao 1 Liao, Bo 1 Lin, Hao 1 Majid, Abdul 1 Mohabatkar, Hassan 1 Mohsenzadeh, Sasan 1 Munteanu, Cristian Robert 1 Pan, Xiao-Yong 1 Peng, Zhen-Ling 1 Perez-Bello, Alcides 1 Ruan, Jishou 1 Sarvestani, Amir Sabet 1 Shen, Hongbin 1 Srinivasasainagendra, Vinodh 1 Stach, Wojciech 1 Suganthan, Ponnuthurai Nagaratnam 1 Ubeira, Florencio M. 1 Uriarte, Eugenio 1 Wang, Desheng 1 Yang, Jianyi 1 Yu, Zuguo 1 Zhang, Li 1 Zhang, Ruijie 1 Zhang, Yanan 1 Zhi, Degui 1 Zhou, Xi-Bin 1 Zhu, Wen 1 Zou, Xiaoyong Cited in 2 Serials 21 Journal of Theoretical Biology 1 Computational Biology and Chemistry Cited in 5 Fields 22 Biology and other natural sciences (92-XX) 7 Computer science (68-XX) 5 Statistics (62-XX) 1 Numerical analysis (65-XX) 1 Game theory, economics, finance, and other social and behavioral sciences (91-XX) Citations by Year