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LASSIE

swMATH ID: 29330
Software Authors: Tangherloni A, Nobile MS, Besozzi D, Mauri G, Cazzaniga P
Description: LASSIE: simulating large-scale models of biochemical systems on GPUs. Results: LASSIE is a “black-box” GPU-accelerated deterministic simulator, specifically designed for large-scale models and not requiring any expertise in mathematical modeling, simulation algorithms or GPU programming. Given a reaction-based model of a cellular process, LASSIE automatically generates the corresponding system of Ordinary Differential Equations (ODEs), assuming mass-action kinetics. The numerical solution of the ODEs is obtained by automatically switching between the Runge-Kutta-Fehlberg method in the absence of stiffness, and the Backward Differentiation Formulae of first order in presence of stiffness. The computational performance of LASSIE are assessed using a set of randomly generated synthetic reaction-based models of increasing size, ranging from 64 to 8192 reactions and species, and compared to a CPU-implementation of the LSODA numerical integration algorithm.
Homepage: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-017-1666-0
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Cited in: 1 Publication

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