swMATH ID: 34250
Software Authors: Wang, J.; Ma, R.; Ma, W.; Chen, J.; Yang, J.; Xi, Y.; Cui, Q.
Description: LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations. LncRNAs represent a large class of noncoding RNA molecules that have important functions and play key roles in a variety of human diseases. There is an urgent need to develop bioinformatics tools as to gain insight into lncRNAs. This study developed a sequence-based bioinformatics method, LncDisease, to predict the lncRNA-disease associations based on the crosstalk between lncRNAs and miRNAs. Using LncDisease, we predicted the lncRNAs associated with breast cancer and hypertension. The breast-cancer-associated lncRNAs were studied in two breast tumor cell lines, MCF-7 and MDA-MB-231. The qRT-PCR results showed that 11 (91.7
Homepage: https://academic.oup.com/nar/article/44/9/e90/2462270
Related Software: starBase; word2vec; LINE; DeepWalk; GitHub; LncADeep; node2vec; ncPred; lncRNAdb
Cited in: 2 Publications

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