LOT swMATH ID: 35330 Software Authors: Zhang, M., Feng, R., Chen, X., Hu, B., Zhang, H. Description: LOT: a tool for linkage analysis of ordinal traits for pedigree data. Summary: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. Availability: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/ Homepage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566542/ Related Software: Cited in: 1 Publication Cited by 1 Author 1 Zhang, Heping Cited in 1 Serial 1 Statistical Science Cited in 2 Fields 1 Statistics (62-XX) 1 Biology and other natural sciences (92-XX) Citations by Year