swMATH ID: 35330
Software Authors: Zhang, M., Feng, R., Chen, X., Hu, B., Zhang, H.
Description: LOT: a tool for linkage analysis of ordinal traits for pedigree data. Summary: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. Availability: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/
Homepage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566542/
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Cited in: 1 Publication

Cited by 1 Author

1 Zhang, Heping

Cited in 1 Serial

1 Statistical Science

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