C-GRAAL swMATH ID: 8317 Software Authors: Vesna Memisevic; Natasa Przulj Description: C-GRAAL: Common-neighbors-based global GRAph ALignment of biological networks. Networks are an invaluable framework for modeling biological systems. Analyzing protein–protein interaction (PPI) networks can provide insight into underlying cellular processes. It is expected that comparison and alignment of biological networks will have a similar impact on our understanding of evolution, biological function, and disease as did sequence comparison and alignment. Here, we introduce a novel pairwise global alignment algorithm called Common-neighbors based GRAph ALigner (C-GRAAL) that uses heuristics for maximizing the number of aligned edges between two networks and is based solely on network topology. As such, it can be applied to any type of network, such as social, transportation, or electrical networks. We apply C-GRAAL to align PPI networks of eukaryotic and prokaryotic species, as well as inter-species PPI networks, and we demonstrate that the resulting alignments expose large connected and functionally topologically aligned regions. We use the resulting alignments to transfer biological knowledge across species, successfully validating many of the predictions. Moreover, we show that C-GRAAL can be used to align human–pathogen inter-species PPI networks and that it can identify patterns of pathogen interactions with host proteins solely from network topology. Homepage: http://bio-nets.doc.ic.ac.uk/C-GRAAL/ Related Software: GEDEVO; SPINAL; CVX; SDPT3; PAML; ACME; ClustalW; Algorithm 97; MODA; MultiPhyl; PathBLAST; Graemlin; MAVisto; Kavosh; NeMoFinder; ParaKMeans; GeneWise; MotifClick; ParaMEME; pCLUSTAL Cited in: 4 Publications all top 5 Cited by 9 Authors 1 Baumbach, Jan 1 Candogan, Utkan Onur 1 Chandrasekaran, Venkat 1 Erciyes, Kayhan 1 Guo, Jiong 1 Ibragimov, Rashid 1 Malek, Maximilian 1 Tadić, Bosiljka 1 Živković, Jelena Cited in 3 Serials 1 Mathematical Programming. Series A. Series B 1 Computational Biology 1 Nanoscale Systems: Mathematical Modeling, Theory and Applications Cited in 4 Fields 3 Combinatorics (05-XX) 3 Operations research, mathematical programming (90-XX) 3 Biology and other natural sciences (92-XX) 1 Computer science (68-XX) Citations by Year