Cellerator swMATH ID: 9926 Software Authors: Shapiro, B.E., Levchenko, A., Meyerowitz, E.M., Wold, B.J., Mjolsness, E.D. Description: Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Summary: Cellerator describes single and multi-cellular signal transduction networks (STN) with a compact, optionally palette-driven, arrow-based notation to represent biochemical reactions and transcriptional activation. Multi-compartment systems are represented as graphs with STNs embedded in each node. Interactions include mass-action, enzymatic, allosteric and connectionist models. Reactions are translated into differential equations and can be solved numerically to generate predictive time courses or output as systems of equations that can be read by other programs. Cellerator simulations are fully extensible and portable to any operating system that supports Mathematica, and can be indefinitely nested within larger data structures to produce highly scaleable models. Availability: Cellerator can be licensed free of charge to noncommercial academic, U.S. government, and nonprofit users. Details and sample notebooks are available at http://www-aig.jpl.nasa.gov/public/mls/cellerator. Homepage: http://bioinformatics.oxfordjournals.org/content/19/5/677.short Related Software: Mathematica; BIOCHAM; STOCHSIM; Matlab; Python; CplexA; pycellerator; Dizzy; Bio-PEPA; PRISM; SICStus; MGS; BLOG; CSPLib; CMBSlib Cited in: 7 Publications all top 5 Cited by 7 Authors 2 Bortolussi, Luca 2 Mjolsness, Eric 2 Policriti, Alberto 2 Van Dyken, J. David 1 Fages, François 1 Soliman, Sylvain 1 Yosiphon, Guy Cited in 4 Serials 2 Journal of Theoretical Biology 1 Bulletin of Mathematical Biology 1 Annals of Mathematics and Artificial Intelligence 1 Constraints all top 5 Cited in 7 Fields 6 Biology and other natural sciences (92-XX) 4 Computer science (68-XX) 2 Operations research, mathematical programming (90-XX) 1 Combinatorics (05-XX) 1 Ordinary differential equations (34-XX) 1 Probability theory and stochastic processes (60-XX) 1 Systems theory; control (93-XX) Citations by Year