an:05312717
Zbl 1140.92011
Ibragimov, A. I.; McNeal, C. J.; Ritter, L. R.; Walton, J. R.
Stability analysis of a model of atherogenesis: an energy estimate approach
EN
Comput. Math. Methods Med. 9, No. 2, 121-142 (2008).
00219600
2008
j
92C50 35Q92 35B35 35K57 92C17 35B40
atherosclerosis; chemotaxis
Summary: Atherosclerosis is a disease of the vasculature that is characterized by chronic inflammation and the accumulation of lipids and apoptotic cells in the walls of large arteries. This disease results in plaque growth in an infected artery typically leading to occlusion of the artery. Atherosclerosis is the leading cause of human mortality in the US, much of Europe, and parts of Asia. In a previous work [see \textit{A. I. Ibragimov} et al., Math. Med. Biol. 22, No. 4, 305--333 (2005; Zbl 1080.92040)], we introduced a mathematical model of the biochemical aspects of the disease, in particular the inflammatory response of macrophages in the presence of chemoattractants and modified low density lipoproteins. Herein, we consider the onset of a lesion as resulting from an instability in an equilibrium configuration of cells and chemical species. We derive an appropriate norm by taking an energy estimate approach and present stability criteria. A bio-physical analysis of the mathematical results is presented.
Zbl 1080.92040